Amino-derivatized phosphoramidite linking agents
US5212304A · kind A · utility
26Cited by
7References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 8, 1988 |
| Grant date | May 18, 1993 |
| Priority date | — |
| Expiry date | Jul 8, 2008 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B37/0039
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.