Super glucocorticoid receptors: receptors with increased affinity and specificity for glucocorticoid steriods
US5215916A · kind A · utility
2Cited by
0References
8Claims
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Assignee
Inventors
Key dates
| Filing date | Jun 19, 1991 |
| Grant date | Jun 1, 1993 |
| Priority date | — |
| Expiry date | Jun 19, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/721
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to novel glucocorticoid receptors that have greater affinity and specifity for glucocorticoid steroids than the naturally occurring receptors. More particularly, the invention relates to the altering of the equivalent of cysteine-656 of the rat glucocorticoid receptor to either serine or glycine for the production of super glucocorticoid receptors which retain full biological activity in intact cells and have higher affinity and specificity for glucocorticoid steroid binding than the original receptor. The invention further relates to the recombinant expression of such altered receptors in host cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.