Process for preparing a vaccine against malaria
US5229110A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Apr 8, 1991 |
| Grant date | Jul 20, 1993 |
| Priority date | — |
| Expiry date | Apr 8, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/822
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing a vaccine against malaria comprising at least one polypeptide extracted from a schizont form of a strain of Plasmodium containing polypeptides antigenic to malaria. The polypeptides are recognized by immunoglobulin from a Saimiri Sciureus monkey resistant to the strain. The process includes the steps of: PA1 (a) treating a preparation of a strain of Plasmodium with a solution of a detergent which is able to separate the cellular structures from the parasite proteinic constituents; PA1 (b) recovering from the treated preparation, a polypeptide fraction having intact polypeptides of molecular weight ranging from about 70,000-85,000 or 90,000-120,000. The polypeptide fraction induces, in a first splenectomized Saimiri Sciureus monkey, a protective antibody against such strain, the polypeptides being recognized by immunoglobulin from a second Saimiri Sciureus monkey resistant to the strain. The immunoglobulin is capable, by an in vivo passive transfer to a third splenectomized Saimiri Sciureus monkey, sensitive to the strain, to protect the third monkey against the strain; and PA1 (c) adding a pharmaceutically acceptable vaccine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.