Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
US5243045A · kind A · utility
88Cited by
6References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 3, 1992 |
| Grant date | Sep 7, 1993 |
| Priority date | — |
| Expiry date | Apr 3, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A taxane derivative of the formula ##STR1## wherein R.sub.1 is phenyl or substituted phenyl, PA0 R.sub.3 is CH.sub.3 O--, or CH.sub.3 CH.sub.2 O--, PA0 Z is --OT.sub.1, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2. PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.