Renin inhibiting compounds

US5250517A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Quirico Branca · Basel, CH
• Albrecht Edenhofer · Basel, CH
• Eva-Maria Gutknecht · Heitersheim, DE
• Werner Neidhart · Hagenthal-le-Bas, FR
• Henri Ramuz · Birsfelden, CH
• Wolfgang Wostl · Weil am Rhein, DE

Key dates

• Filing date: May 4, 1992
• Grant date: Oct 5, 1993
• Expiry date: May 4, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/1024
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Compounds which are amino acid derivatives and have the formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, propyl or imidazol-4-yl, R.sup.3 is isobutyl, cyclohexylmethyl or benzyl, and A is defined as herein are useful as renin inhibitors.