2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents
US5258538A · kind A · utility
25Cited by
10References
27Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 29, 1991 |
| Grant date | Nov 2, 1993 |
| Priority date | — |
| Expiry date | Oct 29, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65842
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The compounds of the invention include novel linking agents comprising 2-substituted-3-protected-1,3,2-oxazaphosphacycloalkanes and their phosphoramidite precursors. The compounds of the invention further include conjugates of the above linking agents with oligonucleotides and polymer supports. The compounds of the present invention are useful for linking organic moieties, such as fluorescent or chromogenic dyes, to polymer supports and oligonucleotides, particularly single- and double-stranded DNA and RNA fragments.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.