Inhibitors for replication of retroviruses and for the expression of oncogene products

US5264423A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Jack S. Cohen · Bethesda, US
• Len Neckers · Bethesda, US
• Cy Stein · New City, US
• She L. Loke · Wheaton, US
• Kazuo Shinozuka · Kazo, JP

Key dates

• Filing date: Nov 16, 1992
• Grant date: Nov 23, 1993
• Expiry date: Nov 16, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/3521
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Phosphorothioate oligodeoxyribonucleotide analogs can be used to prevent replication of foreign nucleic acids in the presence of normal living cells, as well as to inhibit the proliferation of neoplastic cells.