Oligonucleotide analogs with novel linkages
US5264562A · kind A · utility
560Cited by
1References
12Claims
0Family size
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Key dates
| Filing date | Apr 24, 1991 |
| Grant date | Nov 23, 1993 |
| Priority date | — |
| Expiry date | Apr 24, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs wherein one or more phosphodiester linkages between adjacent nucleotides are replaced by an formacetal/ketal type linkage are resistant to nucleases and do not need to exhibit the diastereomerism characteristic of many other oligonucleotide analogs, and thus are capable of strong hybridization to target RNA or DNA. These oligonucleotide analogs are useful in therapies which modulate gene expression using "antisense" or other specifically binding oligomers.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.