Nucleic acid encoding the D.sub.2 /Ml chimeric receptor
US5264565A · kind A · utility
14Cited by
1References
4Claims
0Family size
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Key dates
| Filing date | Jan 22, 1991 |
| Grant date | Nov 23, 1993 |
| Priority date | — |
| Expiry date | Jan 22, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/723
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Chimeric G-protein linked receptors are constructed which retain ligand binding specificity yet gain the ability to elevate intracellular free calcium as a result of agonist binding. This easily assayed function is provided by the insertion of or replacement with sequences substantially homologous to the i3 loop of a second G-protein-linked receptor. Such receptors are employed, for example, in methods of screening for compounds capable of acting as agonists or antagonists of G-protein-linked receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.