Dioxo-tetrahydroquinoline derivatives

US5268378A · kind A · utility

Assignee

• Merck Sharp & Dohme LLC · US

Inventors

• Raymond Baker · Dursley, GB
• Paul D. Leeson · Monmouth Junction, US
• Michael Rowley · Roma, IT
• Graeme I. Sevenson · Sawbridgeworth, GB

Key dates

• Filing date: Jan 22, 1992
• Grant date: Dec 7, 1993
• Expiry date: Jan 22, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D413/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A class of 2,4-dioxo-1,2,3,4-tetrahydroquinoline derivatives, substituted at the 3-position by a range of carbonyl-containing substituents or by a five- or six-membered heteroaromatic moiety, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and/or AMPA antagonist.