DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5270198A · kind A · utility
9Cited by
2References
23Claims
0Family size
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Key dates
| Filing date | Jan 21, 1992 |
| Grant date | Dec 14, 1993 |
| Priority date | — |
| Expiry date | Jan 21, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21069
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.