Derivatives of tetrapeptides as CCK agonists

US5270302A · kind A · utility

Assignee

• Abbott Laboratories · US

Inventors

• Kazumi Shiosaki · Wellesley, US
• Alex M. Nadzan · San Diego, US
• Hana Kopecka · Vernon Hills, US
• Youe-Kong Shue · Taipei, TW
• Mark W. Holladay · San Diego, US
• Chun W. Lin · Wood Dale, US
• Hugh N. Nellans · Mundelein, US

Key dates

• Filing date: Jun 17, 1991
• Grant date: Dec 14, 1993
• Expiry date: Jun 17, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Selective and potent Type-A CCK receptor agonists of formula (I): EQU X--Y--Z--Q (I) or a pharmaceutically acceptable salt thereof, wherein, PA0 X is selected from ##STR1## Y is selected from ##STR2## Z is ##STR3## and Q is ##STR4## or pharmaceutically-acceptable salts thereof, useful in the treatment of gastrointestinal disorders (including gallbladder disorders), central nervous system disorders, insulin-related disorders and pain, as well as in appetite regulation.