Anti-HIV-1 tetrahydroimidazo[1,4]benzodiazepin-2-(thi) ones

US5270464A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Michael Joseph Kukla · Masontown, US
• Henry J. Breslin · Lansdale, US
• Alfons H. M. Raeymaekers · Beerse, BE
• Josephus L. H. Van Gelder · Kasterlee, BE
• Paul Adriaan Jan Janssen · Vosselaar, BE

Key dates

• Filing date: Apr 5, 1993
• Grant date: Dec 14, 1993
• Expiry date: Apr 5, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing anti-HIV-1 activity, compositions containing these compounds as active ingredients, and methods of treating subjects suffering from HIV-1 infection by administering these compounds. The compounds have the basic structure shown in Formula (I): ##STR1##