N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]amide congeners as muscarinic agents

US5274121A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Kenneth A. Jacobson · Silver Spring, US
• Barton James Bradbury · Sharonville, US
• Jesse Baumgold · Bethesda, US

Key dates

• Filing date: Apr 30, 1992
• Grant date: Dec 28, 1993
• Expiry date: Apr 30, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/125
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds, which are muscarinic agents, having the formula ##STR1## wherein Am is --N(R).sub.a).sub.2, --N(R.sub.a).sub.3.sup.+ I.sup.-, --N (CH.sub.2).sub.n', or ##STR2## n' is an integer from 2 to 7 and R.sub.a is an alkyl having 1 to 4 carbon atoms, and each R.sub.a may be the same or different wherein the other substituents are defined hereinbelow.