Butenyl substituted taxanes and pharmaceutical compositions containing them
US5284864A · kind A · utility
53Cited by
10References
6Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 13, 1992 |
| Grant date | Feb 8, 1994 |
| Priority date | — |
| Expiry date | Nov 13, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/55
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Taxane derivatives of the formula ##STR1## wherein R.sub.1 is butenyl, PA0 R.sub.3 is phenyl, PA0 T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, PA0 T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl or monocylic aryl, PA0 Ac is acetyl, and PA0 E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.