Use of hexadecylphosphocholine for the treatment of psoriasis

US5290769A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Hansjorg Eibl · Bovenden, DE
• Clemens Unger · Göttingen, DE
• Jurgen Engel · Alzenau, DE

Key dates

• Filing date: Dec 22, 1992
• Grant date: Mar 1, 1994
• Expiry date: Dec 22, 2012

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The use of alkylphosphoric acid compounds of Formula I EQU R--Y--PO.sub.2.sup..crclbar. --X--R.sub.1 I where in Formula I PA0 R represents a saturated or unsaturated hydrocarbon radical with 12 to 24 carbon atoms or where R represents the group--CH.sub.2 --CHR.sub.3 --CH.sub.2 --Z--R.sub.4 and R.sub.3 is a C.sub.1 -C.sub.6 -alkoxy group or a C.sub.1 -C.sub.6 -alkoxymethyl group, PA0 Z represents oxygen or sulphur and R.sub.4 represents a C.sub.1 -C.sub.24 -alkyl radical, PA0 X is an oxygen atom, NH or NR.sub.2 and Y is an oxygen atom or NH, R.sub.1 is a C.sub.1 -C.sub.8 -alkyl group, or where R.sub.1 represents a C.sub.2 -C.sub.8 -alkyl group which is unsaturated and/or substituted by halogen, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino, tri-C.sub.1 -C.sub.6 -alkylamino, hydroxy, carboxy, C.sub.3 -C.sub.8 -cycloalkyl or phenyl for the preparation of a pharmaceutical composition for combating psoriasis disorders.