N-substituted glycines, inhibitors of phospholipase A.sub.2
US5298652A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 8, 1992 |
| Grant date | Mar 29, 1994 |
| Priority date | — |
| Expiry date | Dec 8, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C237/42
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of the formula ##STR1## R is hydrogen or --CH.sub.2 COOH; m is 0-2, PA0 x is 1-2, with the provision that when x is 2, m is always 0; PA0 R.sub.1 is CH.sub.3 (CH.sub.2).sub.n O--, CH.sub.3 (CH.sub.2).sub.n CONH--, CH.sub.3 (CH.sub.2).sub.n NHCONH--, CH.sub.3 (CH.sub.2).sub.n NHCOO--, HOOC(CH.sub.2).sub.p O-- or R.sub.3 (CH.sub.2).sub.q O--; PA0 R.sub.2 is hydrogen, carboxy, hydroxy, nitro, amino, CH.sub.3 (CH.sub.2).sub.n O--, CH.sub.3 (CH.sub.2).sub.n CONH--, CH.sub.3 (CH.sub.2).sub.n NHCONH--, CH.sub.3 (CH.sub.2).sub.n NHCOO--, HOOC(CH.sub.2).sub.p O--, R.sub.3 (CH.sub.2).sub.q O-- or R.sub.4 [O(CH.sub.2).sub.2 ].sub.r O--, PA1 wherein n is 0-17, p is 1-10, q is 1-12, r is 1-6, PA0 R.sub.3 is 1- or 2- naphthyloxy, 2,3- or 3,4-dihydroxyphenyl, phenyl, phenoxy or substituted phenyl or phenoxy, wherein the substituent is selected from the group consisting of lower alkyl, lower alkoxy, hydroxy, nitro, amino, halo, carboxy or phenyl, and PA0 R.sub.4 is lower alkyl; PA0 and pharmaceutically acceptable salts with bases, are described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.