DNA sequences encoding phospholipase A.sub.2 enzyme and processes for producing enzyme
US5322776A · kind A · utility
35Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 13, 1993 |
| Grant date | Jun 21, 1994 |
| Priority date | — |
| Expiry date | Jan 13, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides novel DNA and peptide sequences encoding a family of phospholipase A.sub.2 enzymes, with specific activities of approximately 20 .mu.mol/min/mg in the mixed micelle assay. These enzymes are useful in methods for detecting the anti-inflammatory potential of various chemical agents. The invention also details novel methods for determining such potential using the novel sequences, methods for making the novel peptides, and methods for developing new anti-inflammatory drugs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.