Apparatus for multiple simultaneous synthesis

US5324483A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Donna Reynolds Cody · Saline, US
• Sheila DeWitt · Auburn, US
• John C. Hodges · Ann Arbor, US
• John S. Kiely · San Diego, US
• Walter H. Moos · Ann Arbor, US
• Michael R. Pavia · Newton, US
• Bruce D. Roth · Ann Arbor, US
• Mel C. Schroeder · Dexter, US
• Charles J. Stankovic · Ann Arbor, US

Key dates

• Filing date: Feb 2, 1993
• Grant date: Jun 28, 1994
• Expiry date: Feb 2, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C40B60/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by co…