Substituted pyrimidines, pyrimidinones and pyridopyrimidines

US5324729A · kind A · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Eric E. Allen · Somerville, US
• William J. Greenlee · Teaneck, US
• Malcolm MacCoss · Freehold, US
• Arthur A. Patchett · Westfield, US

Key dates

• Filing date: Jul 31, 1992
• Grant date: Jun 28, 1994
• Expiry date: Jul 31, 2012

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/6512
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Substituted pyrimidines, pyrimidinones and pyridopyrimidines of formula (I) are as angiotensin II antagonists useful in the treatment of hypertension, ocular hypertension and certain CNS ailments: ##STR1## wherein K is --N(R.sup.8a)--C(.dbd.M) or --N.dbd.C(R.sup.8b) where M is O or NR.sup.22.