Amino acid analogs as CCK antagonists

US5331006A · kind A · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• David C. Horwell · Cambridge, GB
• Julian Aranda · Denzlingen, DE
• Corinne E. Augelli-Szafran · Homewood, US
• Hans-Jurgen Betche · Denzlingen, DE
• Ann Holmes · Dexter, US
• Michael D. Mullican · Needham, US
• Martyn C. Pritchard · St Ives, GB
• Reginald S. Richardson · Haverhill, US
• Edward Roberts
• Bruce D. Roth · Ann Arbor, US
• Bradley Tait · Killingworth, US
• Bharat Kalidas Trivedi · Farmington Hills, US
• Uwe Trostmann · Gundelfingen, DE
• Paul C. Unangst · Ann Arbor, US

Key dates

• Filing date: Jul 12, 1991
• Grant date: Jul 19, 1994
• Expiry date: Jul 12, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/74
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.