Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof
US5342757A · kind A · utility
42Cited by
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10Claims
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Key dates
| Filing date | Nov 13, 1992 |
| Grant date | Aug 30, 1994 |
| Priority date | — |
| Expiry date | Nov 13, 2012 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/857
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention involves monoclonal antibodies which specifically bind to a cell surface antigen characteristic of tumor vascular endothelium. The antigen, referred to as endosialin, is a glycoprotein and has a molecular weight of about 165 kDa as determined by SDS-PAGE. The protein portion of the molecule has a molecular weight of about 95 kDa. Also disclosed are various uses of the monoclonal antibody and the antigen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.