Cat-1 inhibitors, pharmaceutical compositions and methods of use
US5344843A · kind A · utility
20Cited by
8References
38Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 13, 1992 |
| Grant date | Sep 6, 1994 |
| Priority date | — |
| Expiry date | Mar 13, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention relates to compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.2 ' X, Y, Z, A, B, Q and n are as described herein. Their pharmaceutically acceptable salts, and when appropriate, enantiomers, racemates, diastereomers or mixtures thereof or geometric isomer or mixtures thereof, and pharmaceutically acceptable salts thereof. The compounds of formula I inhibit enzyme carnitine acyltransferase 1 (CAT-1) and are therefore useful in the prevention of injury to ischemic tissue, and can limit infarct size, improve cardiac function and prevent arrhythmias during and following a myocardial infarction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.