Glycosyl phospholipid derivatives of nucleosides and their use as medicines
US5358937A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 1992 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Sep 21, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The glycosylphospholipid nucleoside derivatives of the invention are based on the formula: ##STR1## wherein: R.sub.1 is a nucleoside derivative selected from the group consisting of 3'-azidothymidine (AZT); 2', 3'-dideoxythymidine (ddT); and 2'-deoxy-5-fluorouridine (dFU); PA0 R.sub.2 is a hexose or pentose sugar, with the exception of glucose when x is 1; PA0 A is a hydrogen atom or an alkyl or alkoxy chain containing from 5 to 20 carbon atoms, said alkyl or alkoxy chain having at its extremity a group selected from the group consisting of a hydrogen atom and an NR'R" group, wherein R' and R" represent hydrogen or an alkyl group of 1 to 4 carbon atoms; PA0 x is a number from 1 to 12; PA0 y is a number from 1 to 4; and PA0 z is 0 or 1; and further wherein: PA0 attachment of said hexose sugar is at position 1 or position 6 of said hexose sugar, and attachment of said pentose sugar is at position 1 or position 5 of said pentose sugar. The derivatives of the invention are useful for producing pharmaceutical compositions having, in particular, anti-vital properties.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.