Methods for the synthesis of phosphonate esters
US5359115A · kind A · utility
97Cited by
2References
11Claims
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Key dates
| Filing date | Sep 11, 1992 |
| Grant date | Oct 25, 1994 |
| Priority date | — |
| Expiry date | Sep 11, 2012 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/44
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Phosphonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relatively insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.