Antiretroviral tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones

US5371079A · kind A · utility

Assignee

• Janssen Pharmaceutica NA · BE

Inventors

• Michael Joseph Kukla · Masontown, US
• Henry J. Breslin · Lansdale, US
• Alfons H. M. Raeymaekers · Beerse, BE
• Josephus L. H. Van Gelder · Kasterlee, BE
• Paul Adriaan Jan Janssen · Vosselaar, BE

Key dates

• Filing date: Oct 5, 1993
• Grant date: Dec 6, 1994
• Expiry date: Oct 5, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D243/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The compounds are of the class of tetrahydroimidazo[1,4]benzodiazepin-2-(thi)ones possessing antiretroviral, especially anti-HIV-1, activity. An illustrative compound is (+)-S-4,5,6,7-tetrahydro-9-chloro-5-methyl-6-(3-methyl-2-butenyl)imidazo[4 ,5,1-jk][1,4]benzodiazepine-2(1H)-thione. These compounds are represented by the formula: ##STR1## The application also discloses compositions containing these compounds as active ingredients and methods of treating subjects suffering from retroviral infections by administering said compounds.