Rapamycin oximes
US5373014A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 8, 1993 |
| Grant date | Dec 13, 1994 |
| Priority date | — |
| Expiry date | Oct 8, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A compound of the structure ##STR1## wherein R.sup.1 is ##STR2## R.sup.2 is hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, or Ar; PA0 R.sup.3 is hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, or --CO.sub.2 R.sup.8 ; PA0 R.sup.4 is alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, Ar, aminoalkyl, thioalkyl, alkylthioalkyl, hydroxyalkyl, or --CO.sub.2 R.sup.8 ; PA0 R.sup.5 is hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, At, or --CO.sub.2 R.sup.8 ; PA0 R.sup.6 is hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, or Ar; PA0 R.sup.7 is alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, or Ar; PA0 R.sup.8 is hydrogen, alkyl, alkenyl, alkynyl, trifluoromethyl, arylalkyl, fluorenylmethyl, or PA0 Ar; PA0 Y is O or S; PA0 X is .dbd.N--O--(CH.sub.2).sub.f --Z or .dbd.N--O--Ar; PA0 Z is hydrogen, alkenyl, alkynyl, alkoxy, cyano, fluoro, trifluoromethyl, --NR.sup.5 R.sup.6, aryloxy, or Ar; PA0 Ar is aryl which may be optionally mono-, di-, or tri- substituted; PA0 a=0-4; PA0 b=0-1; PA0 c=0-4; PA0 d=0-6; PA0 e=0-6; and PA0 f=0-6; or a pharmaceutically acceptable salt thereof, with the proviso that when f is 0, Z is hydrogen and …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.