Propenoyl-imidazole derivatives

US5376671A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Matthias Muller-Gliemann · Haan, DE
• Jurgen Dressel · Radevormwald, DE
• Peter Fey · Wuppertal, DE
• Rudolf Hanko · Düsseldorf, DE
• Walter Hubsch · Wuppertal, DE
• Thomas Kramer · Wuppertal, DE
• Ulrich Muller · Wuppertal, DE
• Martin Beuck · Milford, US
• Stanislav Kazda · Wuppertal, DE
• Andreas Knorr · Erkrath, DE
• Johannes-Peter Stasch · Wuppertal, DE
• Stefan Wohlfeil · Hilden, DE

Key dates

• Filing date: Apr 6, 1993
• Grant date: Dec 27, 1994
• Expiry date: Apr 6, 2013

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P9/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Propenoyl-imidazole derivatives are prepared by reaction of appropriate imidazoylaldehydes with CH-acidic compounds and subsequent dehydration of the intermediates. The propenoyl-imidazole derivatives can be employed as active compounds in medicaments for the treatment of arterial hypertension and atherosclerosis.