Backbone modified oligonucleotide analogs
US5378825A · kind A · utility
376Cited by
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13Claims
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Assignee
Inventors
Key dates
| Filing date | May 21, 1991 |
| Grant date | Jan 3, 1995 |
| Priority date | — |
| Expiry date | May 21, 2011 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H11/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of the normal phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di- and poly- nucleosides and nucleotides useful in regulating RNA expression and in therapeutics. Methods of synthesis and use are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.