N9 morpholino derivatives of 7,8-disubstituted guanines
US5382580A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | May 27, 1994 |
| Grant date | Jan 17, 1995 |
| Priority date | — |
| Expiry date | May 27, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D473/18
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Immunostimulating 7,8-disubstituted guanine derivatives that also contain a morpholinyl group as a position-9 substituent are disclosed whose structures are represented by formula I ##STR1## wherein X is O or S; R.sup.1 is a hydrocarbyl or substituted hydrocarbyl group having a length of about one to about seven carbon atoms; R.sup.2 is a hydrogen or C.sub.1 -C.sub.8 acyl; R.sup.3 is hydrogen, a C.sub.1 -C.sub.5 aliphatic hydrocarbyl, aralkyl or substituted aralkyl group; and the pharmaceutically acceptable base addition salts thereof. Also disclosed are compositions containing an immunostimulating substituted guanine derivative and processes for using the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.