Peg-interferon conjugates
US5382657A · kind A · utility
242Cited by
37References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 26, 1992 |
| Grant date | Jan 17, 1995 |
| Priority date | — |
| Expiry date | Aug 26, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Substituted PEG-interferon conjugates of formulae IA and IB where PEG is linked by means of activated linking reagents of formulae IIA, IIB, or IIB-1 to an amino group in the interferon, and activated linking reagents of formulae IIA, IIB, or IIB-1. The conjugates are not readily susceptible to in vivo hydrolytic cleavage, have enhanced in vivo half life, and reduce the immunogenicity of the interferon while maintaining biological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.