Variants of tissue plasminogen activator, compositions and methods of use for same
US5385732A · kind A · utility
13Cited by
2References
26Claims
0Family size
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Key dates
| Filing date | Mar 22, 1993 |
| Grant date | Jan 31, 1995 |
| Priority date | — |
| Expiry date | Mar 22, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y304/21069
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A fibrinolytically active amino acid sequence variant of a plasminogen activator is prepared that has one or more glycosylation sites in regions that are not glycosylated in the native molecule. DNA sequences can be prepared that encode the variants, as well as expression vectors incorporating the DNA sequences, and host cells transformed with the expression vectors. The variants may be used in a pharmaceutical preparation to treat a vascular disease or condition in patients.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.