Patent · US Expired

Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling

US5386023A · kind A · utility

464Cited by

2References

20Claims

0Family size

Assignee

Isis Pharmaceuticals, Inc. · US

Inventors

Yogesh S. Sanghvi · Encinitas, US
Phillip Dan Cook · Carlsbad, US

Key dates

Filing date	Mar 31, 1993
Grant date	Jan 31, 1995
Priority date	—
Expiry date	Mar 31, 2013

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07H19/16
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Methods for preparing oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. In preferred embodiments, the methods involve reductive coupling of 3'- and 4'-substituted or 4'- and 3'-substituted nucleosidic synthons.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.