Amino alkanoic esters of rapamycin
US5389639A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 29, 1993 |
| Grant date | Feb 14, 1995 |
| Priority date | — |
| Expiry date | Dec 29, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention provides a compound of the structure ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen or ##STR2## R.sup.3 is --(CH.sub.2).sub.q CO.sub.2 R.sup.6 ; PA0 R.sup.4 is hydrogen, alkyl, or arylalkyl; PA0 R.sup.5 is hydrogen or COOR.sup.7 ; PA0 R.sup.6 is hydrogen, alkyl, alkenyl, arylalkyl, fluorenylmethyl, or phenyl which is optionally substituted; PA0 R.sup.7 is alkyl, alkenyl, arylalkyl, fluorenylmethyl, or phenyl which is optionally substituted; PA0 m is 0-4; PA0 n is 0-4; PA0 p is 1-2; PA0 q is 0-4; wherein R.sup.3, R.sup.4, m, and n are independent in each of the ##STR3## subunits when p=2; with the proviso that R.sup.1 and R.sup.2 are not both hydrogen; and further provided that if R.sup.5 is CO.sub.2 R.sup.7, then R.sup.6 is hydrogen; and still further provided that if R.sup.6 is not hydrogen, then R.sup.5 is hydrogen; PA0 or a pharmaceutically acceptable salt thereof which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.