Oligonucleotides with inverted polarity
US5399676A · kind A · utility
490Cited by
2References
32Claims
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Assignee
Inventor
Key dates
| Filing date | Jul 30, 1990 |
| Grant date | Mar 21, 1995 |
| Priority date | — |
| Expiry date | Jul 30, 2010 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/81
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Oligonucleotides having tandem sequences of inverted polarity, i.e., oligonucleotides comprising regions of the formula: ##STR1## wherein --C-- symbolizes any method of coupling the nucleotide sequence of opposite polarity, are useful for forming an extended triple helix with a double-helical nucleotide duplex. The inverted polarity also stabilizes the single-strand oligonucleotides to exonuclease degradation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.