Stable and active metabolites of 1,25-dihydroxy-16-ene-cholecalciferol
US5401733A · kind A · utility
5Cited by
21References
18Claims
0Family size
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Inventors
Key dates
| Filing date | Oct 1, 1993 |
| Grant date | Mar 28, 1995 |
| Priority date | — |
| Expiry date | Oct 1, 2013 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the compounds 1,25-dihydroxy-16-ene-24-oxo-cholecalciferol and 1,24,25-trihydroxy-16-ene-cholecalciferol which stimulate differentiation of HL-60 cells, rendering them useful as an agent for the treatment of neoplastic diseases such as leukemia, and also decrease proliferation of human keratinocytes, rendering them useful as an agent for the treatment of hyperproliferative disorders of the skin such as psoriasis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.