Alkyl camptothecin compounds as potent inhibitors of human colorectal cancer
US5401747A · kind A · utility
21Cited by
17References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 31, 1994 |
| Grant date | Mar 28, 1995 |
| Priority date | — |
| Expiry date | May 31, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for synthesizing camptothecin and camptothecin analogs using a novel hydroxyl-containing tricyclic intermediate and the camptothecin analogs produced by the process. The camptothecin analogs are effective inhibitors of topoisomerase. I and show antileukemic and anti-tumor activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.