Large scale photolithographic solid phase synthesis of an array of polymers

US5405783A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• Michael C. Pirrung · Durham, US
• J. Leighton Read · Palo Alto, US
• Stephen P. A. Fodor · Palo Alto, US
• Lubert Stryer · Stanford, US

Key dates

• Filing date: Mar 12, 1992
• Grant date: Apr 11, 1995
• Expiry date: Mar 12, 2012

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T436/2575
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A technique for the synthesis of arrays of diverse polymers such as polypeptides and nucleic acids. The technique beneficially utilizes solid-phase chemistry techniques. Preferred embodiments utilize photolabile protecting groups, and photolithography. The technique forms polymers with monomer sequences and locations determined by the order of addition of monomers and the activation patterns formed on the substrate.