Antimalarial korupensamines and pharmaceutical compositions and medical uses thereof

US5409938A · kind A · utility

Assignee

• The United States of America, as represented by the Secretary, Department of Health and Human Services · US

Inventors

• Michael R. Boyd · Mobile, US
• Guido Francois · Oostende, BE
• Gerhard Bringmann · Würzburg, DE
• Yaii F. Hallock · Ellicott City, US
• Kirk P. Manfredi · Cedar Falls, US
• John H. Cardellina, II · Fort Detrick, US

Key dates

• Filing date: Feb 14, 1994
• Grant date: Apr 25, 1995
• Expiry date: Feb 14, 2014

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides new antimalarial compounds called korupensamines, korupensamine derivatives, and pharmacologically acceptable salts thereof, methods for isolating such antimalarial korupensamines from the plant Ancistrocladus korupensis, methods for obtaining new korupensamine derivatives, antimalarial compositions containing such antimalarial korupensamines or derivatives thereof or pharmacologically acceptable salts thereof, and methods of using such antimalarial compounds for the prevention of malaria infections or for treating mammals with malarial infections. The antimalarial compounds of the present invention inhibit the reproduction and cytopathicity of Plasmodium sp. parasites in vitro and in vivo.