Steroid modified oligonucleotides
US5416203A · kind A · utility
275Cited by
1References
6Claims
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Assignee
Inventor
Key dates
| Filing date | Jul 26, 1993 |
| Grant date | May 16, 1995 |
| Priority date | — |
| Expiry date | Jul 26, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J51/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An oligonucleotide conjugated to a steroid the oligonucleotide comprising: ##STR1## wherein A is selected from the group consisting of an aliphatic alkyl, branched aliphatic alkyl and an alkyl (branched) chain of 2 to 18 carbon atoms, R is selected from the group consisting of H and lower alkyl up to 12 carbon atoms; B is a naturally occurring base, the steroid is bound to the oligonucleotide utilizing the naturally occurring bases through an (-oxycarbonyl-amino)-decylamine-moiety, and NUC is an oligonucleotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.