Stable bactericidal/permeability-increasing protein muteins
US5420019A · kind A · utility
47Cited by
17References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 2, 1993 |
| Grant date | May 30, 1995 |
| Priority date | — |
| Expiry date | Feb 2, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/44
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are novel bactericidal/permeability-increasing (BPI) protein products wherein cysteine residue number 132 or 135 is replaced by another amino acid residue, preferably an alanine or serine residue and/or wherein the leucine residue at position 193 is the carboxy terminal residue. Also disclosed are DNA sequences encoding methods for the production of the same in appropriate host cells, and stable homogeneous pharmaceutical compositions containing the analogs suitable for use treatment of gram negative bacterial infection and its sequelae.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.