Phenylsulfonylamide pyrimidine

US5420129A · kind A · utility

Assignee

• Hoffmann-La Roche Inc. · US

Inventors

• Volker Breu · Schliengen, DE
• Kaspar Burri · Binningen, CH
• Jean-Marie Cassal · Mulhouse, FR
• Martine Clozel · Binningen, CH
• Georges Hirth · Colmar, FR
• Bernd-Michael Loffler · Oberrimsingen, DE
• Marcel Muller · Frenkendorf, CH
• Werner Neidhart · Hagenthal-le-Bas, FR
• Henri Ramuz · Birsfelden, CH

Key dates

• Filing date: Dec 8, 1993
• Grant date: May 30, 1995
• Expiry date: Dec 8, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The invention is concerned with novel sulphonamides and their use as medicaments. In particular, the invention is concerned with compounds of the formula ##STR1## wherein R.sup.1 is hydrogen, lower-alkyl, lower-alkoxy, lower-alkylthio, halogen or trifluoromethyl; PA0 R.sup.2 is hydrogen, lower-alkyl, halogen, lower-alkoxy, trifluoromethyl or --OCH.sub.2 COOR.sup.9 ; PA0 R.sup.3 is hydrogen, lower-alkyl, halogen, lower-alkylthio, trifluoromethyl, lower-alkoxy or trifluoromethoxy; PA0 R.sup.2 and R.sup.3 together are butadienyl, methylenedioxy, ethylenedioxy or isopropylidenedioxy; PA0 R.sup.4 is hydrogen, lower-alkyl, trifluoromethyl, lower-alkoxy, lower-alkylthio, hydroxy-lower-alkyl, hydroxy-lower-alkoxy, hydroxy-lower-alkoxy-lower-alkyl, hydroxy-lower-alkoxy-lower-alkoxy, alkoxy-lower-alkyl, alkoxy-lower-alkyloxy, lower-alkylsulfinyl, lower-alkylsulfonyl, 2-methoxy-3-hydroxypropoxy, 2-hydroxy-3-phenylpropyl, amino-lower-alkyl, lower-alkylamino-lower-alkyl, di-lower-alkylamino-lower-alkyl, amino, lower-alkylamino, di-lower-alkylamino, arylamino, aryl, arylthio, aryloxy, aryl-lower-alkyl, heterocyclyl, heterocyclo-lower-alkyl, heterocyclylamino, heterocyclylthio, heterocyclyloxy, -…