Methods for the synthesis of phosphonate esters
US5420328A · kind A · utility
70Cited by
2References
11Claims
0Family size
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Key dates
| Filing date | Sep 9, 1993 |
| Grant date | May 30, 1995 |
| Priority date | — |
| Expiry date | Sep 9, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/40
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Phsophonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relativly insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthesize large collections of compounds to screen for pharmacological activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.