Very large scale immobilized polymer synthesis
US5424186A · kind A · utility
956Cited by
8References
17Claims
0Family size
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Key dates
| Filing date | Dec 6, 1991 |
| Grant date | Jun 13, 1995 |
| Priority date | — |
| Expiry date | Dec 6, 2011 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/809
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for synthesizing oligonucleotides on a solid substrate. The method provides for the irradiation of a first predefined region of the substrate without irradiation of a first predefined region of the substrate. The irradiation of a second predefined region of the substrate. The irradiation step removes a protecting group therefrom. The substrate is contacted with a first nucleotide to couple the nucleotide to the substrate in the first predefined region. By repeating these steps, an array of diverse oligonucleotides is formed on the substrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.