Cyclodextrin glycosides and processes for their preparation

US5426184A · kind A · utility

Assignee

• The United States of America, as represented by the Department of Health and Human Services · US

Inventors

• Josef Pitha · Baltimore, US
• Thomas Wimmer · Rosenheim, DE

Key dates

• Filing date: Feb 11, 1993
• Grant date: Jun 20, 1995
• Expiry date: Feb 11, 2013

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B37/0012
• WIPO field: Macromolecular chemistry, polymers
• WIPO sector: Chemistry

Abstract

The invention relates to cyclodextrin glycosides and processes for their preparation. The cyclodextrin glycosides according to the invention are cyclodextrins substituted by 2-acetamido-2-deoxyaldoses. These cyclodextrin glycosides are prepared by a process which is characterized in that cyclodextrins are reacted with 2-acetamido-2-deoxyaldoses in an anhydrous acid medium and the reaction products are then treated with a mild base. The cyclodextrin glycosides can be used for solubilization of substances which are sparingly soluble or insoluble in water.