Oligonucleotides having selectably cleavable and/or abasic sites
US5430136A · kind A · utility
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8Claims
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Key dates
| Filing date | Jul 27, 1990 |
| Grant date | Jul 4, 1995 |
| Priority date | — |
| Expiry date | Jul 27, 2010 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/11
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Polynucleotides containing abasic, cleavable sites are provided. These polynucleotides are useful in a variety of biochemical and chemical contexts, particularly in solid phase nucleic acid hybridization assays because a captured probe can be released from the support. The polynucleotides have the structure ##STR1## where R is selected from the group consisting of 2-nitrobenzyl, 4-penten-1-yl, ##STR2## where R', R.sub.i and R.sub.j are as defined herein. One of the preferred embodiments is a polynucleotide where R is ##STR3##
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.