Peptide library and screening systems

US5432018A · kind A · utility

Assignee

• Affymax Technologies N.V. · NL

Inventors

• William J. Dower · Menlo Park, US
• Steven E. Cwirla · Menlo Park, US
• Ronald W. Barrett · Saratoga, US

Key dates

• Filing date: Jun 20, 1991
• Grant date: Jul 11, 1995
• Expiry date: Jun 20, 2011

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Peptides which bind to selected receptors are identified by screening libraries which encode a random or controlled collection of amino acids. Peptides encoded by the libraries are expressed as fusion proteins of bacteriophage coat proteins, and bacteriophage are then screened against the receptors of interest. Peptides having a wide variety of uses, such as therapeutic or diagnostic reagents, may thus be identified without any prior information on the structure of the expected ligand or receptor.