Binding compentent oligomers containing unsaturated 3',5' and 2',5' linkages
US5434257A · kind A · utility
490Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 26, 1993 |
| Grant date | Jul 18, 1995 |
| Priority date | — |
| Expiry date | Oct 26, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/319
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Oligonucleotide analogs having one or more substitute linkages of the formula 2'/3'--S--CH.sub.2 --CH.dbd.5' or 2'/3'--O--CH.sub.2 --CH.dbd.5' between adjacent nucleomonomers are disclosed. The substitute linkage replace the usual phosphodiester linkage found in unmodified nucleic acids. The oligonucleotide analogs are easy to synthesize, stable in vivo, resistant to endogenous nucleases and are able to hybridize to target nucleic acid sequences in a sequence specific manner.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.