Surface fluorescent monitor

US5435307A · kind A · utility

Assignee

• The United States of America as Represented by the Secretary of the Department of Health and Human Services · US

Inventors

• Walter S. Friauf · Bethesda, US
• Paul D. Smith · Redondo Beach, US
• John W. Cole · Aliso Viejo, US
• Joseph F. Fessler · Walkersville, US
• Roger E. Solomon · Watchung, US
• Eric F. Bernstein · Lansdowne, US

Key dates

• Filing date: Mar 29, 1991
• Grant date: Jul 25, 1995
• Expiry date: Mar 29, 2011

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/0059
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A method of optimizing photodynamic therapy in which retained concentrations of photosensitizers administered are measured on a real time basis by percutaneous measurements of fluorescence. A light weight hand held fluorometer is used to percutaneously measure fluorescence emitted by photosensitizers in a tissue situs that is subject to photodynamic therapy. The use of real time determinations of the concentration of photosensitizers allow optimization of illumination intensity and duration.