Method of inhibiting blood coagulation in extracorporeal circulation by inhibiting human tissue factor

US5437864A · kind A · utility

Assignees

• THE SCRIPPS RESEARCH INSTITUTE · US
• The Trustees of the University of Pennsylvania · US
• Temple University-Of The Commonwealth System of Higher Education · US

Inventors

• Thomas S. Edgington · Village of La Jolla, US
• Robert W. Colman · Moylan, US
• Janos Kappelmayer · Debrecen, HU
• L. Henry Edmunds, Jr. · Via Enrico Fermi, US
• Alvise Bernabei · Philadelphia, US

Key dates

• Filing date: Nov 16, 1992
• Grant date: Aug 1, 1995
• Expiry date: Nov 16, 2012

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/745
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides a method of inhibiting coagulation in extracorporeal circulation in a subject, comprising administration of a therapeutically effective amount of a monoclonal antibody which inhibits the ability of tissue factor to bind to factor VII/VIIa. The method prevents complex formation between tissue factor and factor VII/VIIa and thus inhibits coagulation of blood in extracorporeal procedures such as cardiopulmonary bypass and other shunt procedures. Anti-tissue factor monoclonal antibodies produced by hybridoma cell lines TFS-5G9 or TF9-6B4 may be used in the claimed methods.